General Information

  • ID:  hor000937
  • Uniprot ID:  B3EWM3
  • Protein name:  Sulfakinin 6-14
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Gastrin/cholecystokinin family
  • Source:  animal
  • Expression:  Detected in larvae and adults. |In larvae, both sulfakinin and sulfakinin(6-14) are expressed in the CNS but not the ring gland, thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO) (at protein level). In adults, both sulfaki
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FDDYGHMRF
  • Length:  9
  • Propeptide:  GGEEQFDDYGHMRF
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic peptide.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000937_AF2.pdbhor000937_ESM.pdb

Physical Information

Mass: 133017 Formula: C54H70N14O15S
Absent amino acids: ACEIKLNPQSTVW Common amino acids: DF
pI: 5.41 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -98.89 Boman Index: -2791
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: 478.89 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).
  • PubMed ID:  22848525
  • Title:   Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).